E-Phys is an independent contract research organization (CRO) specialized in preclinical electrophysiology in anesthetized rodents for analgesic drugs RND.
The opioid crisis has highlighted an old issue : developing innovative and powerful pain killers without side effects. This is a tough task. One hurdle is that analgesic efficacy of drug candidates is classically assessed using behavioural tests, which are sensitive to anxiolytic and/or sedative activity in addition to analgesic activity.
Analgesic potency can only be specifically assessed by measuring drug effects on the activity of neurons at the origin of pain sensation in vivo. This is what we do.
E-Phys is an independent CRO specializing in electrophysiology in anesthetized rodents for the development of analgesic drug, founded in 2012 and based in Clermont-Ferrand, France. E-Phys can be considered a legacy of the in vivo electrophysiology group of the late (2011) Pfizer Global Research and Development based in Sandwich, UK.
The founder, Julien Allard, was initially graduated as a biochemist (1991, INSA, Lyon, France). This was followed by a Master and a PhD in Pharmacology and Neurosciences (1999, Université René Descartes, Paris, France). Julien Allard started his career in electrophysiology at Pfizer in 2008. He has largely passed the some-consider-it-to-be-a-landmark-for-expertise 10 000 h over the bench of single-unit recordings in anesthetized rodents since.