E-Phys is an independent contract research organization (CRO) specialized in preclinical electrophysiology in anesthetized rodents.
The opioid crisis has highlighted an old issue : developing innovative and powerful pain killers without side effects. This is a tough task. One hurdle is that analgesic efficacy of drug candidates is classically assessed using behavioural tests, which are sensitive to anxiolytic and/or sedative activity in addition to analgesic activity.
Analgesic potency can only be specifically assessed by measuring drug effects on the activity of neurons at the origin of pain sensation in vivo. This is what we do.