Our core expertise is to perform extracellular recording of single-units at all essential stages of the ascending pain pathway, i.e. at the level of the DRG, the spinal cord, and occasionally the parabrachial area. Routine experiments include recording of unmyelinated DRG neurons (aka C-fibre), lamina I spinoparabrachial neurons and lamina III-V neurons of unknown projections in mice or rats.
Experiments are designed to assess the effect of pathophysiological conditions (e.g. neuropathy) and/or drug treatments on the activity of the key players at the origin of pain sensation. Examples of exploratory experiments and pharmacological studies can be found in the “Publications” page.
Illustrations
